Defining critical roles for NF-kB p65 and type I interferon in innate immunity to rhinovirus
نویسندگان
چکیده
(1) Department of Respiratory Medicine, National H Imperial College London, London, UK (2) MRC and Asthma UK Centre in Allergic Mechanism UK (3) Centre for Respiratory Infections, Imperial College L (4) Sezione di Malattie dell’Apparato Respiratorio, Cent Malattie Infiammatorie Croniche delle Vie Aeree Correlate dell’Apparato Respiratorio (CEMICEF), U Ferrara, Italy (5) Respiratory Pharmacology, National Heart and Lun College London, London, UK (6) Imperial College Healthcare National Health Servic (7) The Pulmonary Centre, Boston University School Massachusetts, USA (8) Department of Biochemistry and Molecular Biology Cancer Center, UMDNJ-New Jersey Medical School, *Corresponding author: Tel: þ44 0 20 7594 3775; Fax: E-mail: [email protected]
منابع مشابه
Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus
The importance of NF-κB activation and deficient anti-viral interferon induction in the pathogenesis of rhinovirus-induced asthma exacerbations is poorly understood. We provide the first in vivo evidence in man and mouse that rhinovirus infection enhanced bronchial epithelial cell NF-κB p65 nuclear expression, NF-κB p65 DNA binding in lung tissue and NF-κB-regulated airway inflammation. In vitr...
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